Steve and Corey speak with Stuart Firestein (Professor of Neuroscience at Columbia University, specializing in the olfactory system) about his two books Ignorance: How It Drives Science and Failure: Why Science Is So Successful. Stuart explains why he thinks that it is a mistake to believe that scientists make discoveries by following the “scientific method” and what he sees as the real relationship between science and art. We discuss Stuart’s recent research showing that current models of olfactory processing are wrong, while Steve delves into the puzzling infinities in calculations that led to the development of quantum electrodynamics. Stuart also makes the case that the theory of intelligent design is more intelligent than most scientists give it credit for and that it would be wise to teach it in science classes.